Research

I study the evolution of cancer using mathematical modeling. In particular, I use stochastic processes to model the process of cancer initiation from healthy tissue to invasive cancer in a spatially structured environment. I also study the evolution of drug resistance in glioblastoma, and particularly the role of MGMT methylation, in order to determine optimal treatment strategies. Other current topics of interest are the use of oncolytic viral therapy to treat cancer and the resulting immune dynamics, data-driven modeling of tumor growth, uncertainty quantification, and data analytic methods deriving from topology. My publications and preprints are listed below.

Publications

• H. Cho*, A.L. Lewis*, K.M. Storey*, A. Zittle, ‘An Adaptive information-theoretic experimental design procedure for high-to-low fidelity calibration of prostate cancer models,’ Mathematical Biosciences and Engineering (2023) 20(10): 17986-18017. https://doi.org/10.3934/mbe.2023799.
  (* indicates equal contribution)

• E.J. Amézquita, F. Nasrin, K.M. Storey, M. Yoshizawa, ‘Genomics Data Analysis via Spectral Shape and Topology,‘ PLoS One (2023) 18(4): e0284820, https://doi.org/10.1371/journal.pone.0284820.

• J. Foo, E.B. Gunnarsson, K. Leder, K.M. Storey. ‘Spread of premalignant mutant clones and cancer initiation in multilayered tissue,’ Annals of Applied Probability (2023) 33(1), p. 299-343, https://doi.org/10.1214/22-AAP1816.

• H. Cho*, A.L. Lewis*, K. M. Storey*, Helen M. Byrne. ‘Designing experimental conditions to use the Lotka-Volterra model to infer tumor cell line interaction types,‘ Journal of Theoretical Biology (2023) 559:111377, https://doi.org/10.1016/j.jtbi.2022.111377.
  (* indicates equal contribution)

• J. Alvarez, K.M. Storey, P. Kannan, H. Cho. ‘Effective dose fractionation schemes of radiotherapy for prostate cancer,’ Spora: A Journal of Biomathematics (2022) 8: p. 16-30.

• K.M. Storey, T.L. Jackson. ‘An agent-based model of combination oncolytic viral therapy and anti-PD-1 immunotherapy reveals the importance of spatial location when treating glioblastoma,’ Cancers (2021) 13(21), 5314, https://doi.org/10.3390/cancers13215314.

• H. Cho*, A.L. Lewis*, K. Storey*, R. Jennings, B. Shtylla, A.M. Reynolds, H. Byrne. ‘A Framework for Performing Data-Driven Modeling of Tumor Growth with Radiotherapy Treatment,’ Springer Special Issue: Using Mathematics to Understand Biological Complexity, Association for Women in Mathematics Series 22 (2021).
  (* indicates equal contribution)

• H. Cho*, A.L. Lewis*, K. Storey*. ‘Bayesian information-theoretic calibration of radiotherapy sensitivity parameters for informing effective scanning protocols in cancer,‘ Journal of Clinical Medicine (2020) 9(10), 3208, https://doi.org/10.3390/jcm9103208.
  (* indicates equal contribution)

• K. Storey, S. Lawler, T. Jackson. ‘Modeling oncolytic viral therapy and the complex dynamics of innate and adaptive immunity,‘ Frontiers in Physiology (2020) 11: 151. doi: 10.3389/fphys.2020.00151.

• D. Bhaskar, A. Manhart, J. Milzman, J. Nardini, K. Storey, C. Topaz, L. Ziegelmeier. ‘Analyzing collective motion with machine learning and topology,‘ Chaos: An Interdisciplinary Journal of Nonlinear Science (2019) 29(12): 123125, https://doi.org/10.1063/1.5125493.

• K. Storey, K. Leder, A. Hawkins-Daarud, K. Swanson, A. Ahmed, R. Rockne, J. Foo. ‘Glioblastoma recurrence and the role of MGMT promoter methylation,‘ Journal of Clinical Oncology – Clinical Cancer Informatics (2019) 3: p. 1-12.

• K. Storey, M. Ryser, K. Leder, J. Foo. ‘Spatial measures of genetic heterogeneity during carcinogenesis,’ Bulletin of Mathematical Biology (2017) 79(2): p. 237-276.

• X. Wang, J.R. Walton, R.D. Parshad, K. Storey, M. Boggess. ‘Analysis of the Trojan Y- Chromosome eradication strategy for an invasive species,’ Journal of Mathematical Biology (2014) 68(7): p. 1731-1756.