Brewer, Alison (Campbell)

B.S.: Biochemistry in 2004

Ph.D.: Inorganic Chemistry at the University of North Carolina with Mike Gagné in 2008

Post-doc: University of Wisconsin with Shannon Stahl

Senior Research Scientist: Eli Lilly in Indianapolis, IN

Publications

  • “Discovery of LY3104607: A potent and selective G protein-coupled receptor 40 (GPR40) agonist with optimized pharmacokinetic properties to support once daily oral treatment in patients with type 2 diabetes mellitus.” C. Hamdouchi, P. Maiti, A.M. Warshawsky, A.C. DeBaillie, K.A. Otto, K.L. Wilbur, S.D. Kahl, A. Patel Lewis, G.R. Cardona, R.W. Zink, K. Chen, Siddaramaiah CR, J.P. Lineswala, G.L. Neathery, C. Bouaichi, B.A. Diseroad, A.N. Campbell, S.A. Sweetana, L.A. Adams, O. Cabrera, X. Ma, N.P. Yumibe, C. Montrose-Rafizadeh, Y. Chen and A. Reifel Miller, J. Med. Chem. 2018, 61, 934.
  • “Scalable synthesis of enantiopure bis-3,4-diazaphospholane ligands for asymmetric catalysis.” B.R. Jones, M.L. Abrams, C.R. Landis, S.A. May, A.N. Campbell, J.R. Martinelli and J.R. Calvin, J. Org. Chem., 2016, 81, 11965.
  • “Development and manufacturing GMP scale-up of a continuous Ir-catalyzed homogeneous reductive amination reaction.” S.A. May, M.D. Johnson, J.Y. Buser, A.N. Campbell, S.A. Frank, B.D. Haeberle, P.C. Hoffman, G.R. Lambertus, A.D. McFarland, E.D. Moher, T.D. White, D.D. Hurley, A.P. Corrigan, O. Gowran, N.G. Kerrigan, M.G. Kissane, R.R. Lynch, P. Sheehan and R.D. Spencer, Org. Process Res. Dev., 2016, 20, 1870.
  • “Use of modeling and process analytical technologies in the design of a catalytic amination reaction: Understanding oxygen sensitivity at the lab and manufacturing scales.” J.M. Merritt, J.Y. Buser, A.N. Campbell, J.W. Fennell, N.J. Kallman, T.M. Koenig, H. Moursy, M.A. Pietz, N. Scully and U.K. Singh, Org. Proc. Res. Dev. 2014, 18, 246.
  • “Ruthenium(III) chloride.” A.N. Campbell, C.-M. Che, E.S. Gore, J.A. McKinney and M.-K. Wong, Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents, 2013, 549.
  • “Development of an alternate synthesis for a key JAK2 inhibitor intermediate via sequential C-H bond functionalization.” A.N. Campbell, K.P. Cole, J.R. Martinelli, S.A. May, D. Mitchell, P.M. Pollock and K. A. Sullivan, Org. Proc. Res. & Dev. 2013, 17, 273.
  • “Overcoming the ‘Oxidant Problem’: Strategies to use O2 as the oxidant in organometallic C-H oxidation reactions catalyzed by Pd (and Cu).” A.N. Campbell and S.S. Stahl, Acc. Chem. Res. 2012, 45, 851.
  • “Regiocontrolled aerobic oxidative coupling of indoles and benzene using Pd catalysts with 4,5-diazafluorene ligands.” A.N. Campbell, E.B. Meyer and S.S. Stahl, Chem. Commun., 2011, 47, 10257.
  • “Allylic C-H acetoxylation with a 4,5-diazafluorenone-ligated palladium catalyst: A ligand-based strategy to achieve aerobic catalytic turnover.” A.N. Campbell, P.B. White, I.A. Guzei and S.S. Stahl, J. Am. Chem. Soc., 2010, 132, 15116.
  • “Asymmetric oxidative cation/olefin cyclization of polyenes: Evidence for reversible cascade cyclization.” C. A. Mullen, A. N. Campbell and M. R. Gagne, Angew. Chem. Int. Ed., 2008, 47, 6011.
  • “ERb ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor b-selective ligands.” A. T. Vu, A. N. Campbell, H. A. Harris, R. J. Unwalla, E. S. Manas, R. E. Mewshaw, Bioorg. Med. Chem. Let., 2007, 17, 4053.
  • “Room-temperature b-H elimination in (P2P)Pt(OR) cations: convenient synthesis of a platinum hydride.” A. N. Campbell and M. R. Gagne, Organometallics, 2007, 26, 2788.
  • “Modular catalysts for diene cycloisomerization: Rapid and enantioselective variants for bicyclopropane synthesis.” J. A. Feducia, A. N. Campbell, M. Q. Doherty and M. R. Gagne, J. Am. Chem. Soc., 2006, 128, 12390.
  • “Protonolysis of cationic Pt-C bonds with mild acids: Can ligand torsional effects speed associative processes?” J. A. Feducia, A. N. Campbell, J. W. Anthis and M. R. Gagne, Organometallics, 2006, 25, 3114.
  • “Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones.” A. N. Campbell and J. Sherma, Journal of Liquid Chromatography & Related Technologies, 2003, 26, 2719.
  • “Use of a modified flatbed scanner for documentation and quantification of thin layer chromatograms detected by fluorescence quenching.” A. Campbell, M. J. Chejlava and J. Sherma, Journal of Planar Chromatography–Modern TLC 2003, 16, 244.