- Where do we go from here?
- Understanding that:
- There is considerable diversity in the expression dynamics of p53 target genes
- This diversity is p53 dependent
- Results are consistent with model prediction that mRNA decay rate determines gene expression dynamics
Current approaches for p53 targeting
- What experiment could be performed to verify that p53 pulsing generate diversity in dynamics?
- Next step in discovering how to arrest the cell cycle in cancer prevention methods
- A better understanding of how signaling dynamics are regulated and how they affect cellular responses will provide new insights for manipulating them in a controlled way
- In addition, targeted perturbation of protein dynamics, may enable new pharmacological strategies for altering cell fate in a range of diseases
- Understanding the undercurrents of the cells and genes could also assist in best understanding how to prevent uncontrollable cell growth
- Understanding that:
Structure of Small-Molecule p53 Activators, Reactivators, and Inhibitors.
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